{"id":678,"date":"2019-11-24T16:18:14","date_gmt":"2019-11-24T13:18:14","guid":{"rendered":"https:\/\/niox.com.ua\/?page_id=678"},"modified":"2020-08-12T22:51:24","modified_gmt":"2020-08-12T19:51:24","slug":"publications-whitepapers","status":"publish","type":"page","link":"https:\/\/niox.com.ua\/ru\/publications-whitepapers\/","title":{"rendered":"\u041f\u0443\u0431\u043b\u0438\u043a\u0430\u0446\u0438\u0438 \u0438 \u0442\u0435\u0445\u043d\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u0434\u043e\u043a\u0443\u043c\u0435\u043d\u0442\u044b"},"content":{"rendered":"<div id='my_fblock'  class='avia-section main_color avia-section-large avia-shadow avia-bg-style-scroll  avia-builder-el-0  el_before_av_one_full  avia-builder-el-first   container_wrap sidebar_right' style=' '  ><div class='container' ><main  role=\"main\" itemprop=\"mainContentOfPage\"  class='template-page content  av-content-small alpha units'><div class='post-entry post-entry-type-page post-entry-678'><div class='entry-content-wrapper clearfix'>\n<div class=\"flex_column av_one_full  flex_column_div av-zero-column-padding first  avia-builder-el-1  el_before_av_one_half  avia-builder-el-first  \" style='border-radius:0px; '><p><div  style='padding-bottom:10px; color:#011642;' class='av-special-heading av-special-heading-h1 custom-color-heading blockquote modern-quote  avia-builder-el-2  el_before_av_textblock  avia-builder-el-first  '><h1 class='av-special-heading-tag '  itemprop=\"headline\"  >\u041f\u0443\u0431\u043b\u0438\u043a\u0430\u0446\u0438\u0438 \u0438 \u0442\u0435\u0445\u043d\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u0434\u043e\u043a\u0443\u043c\u0435\u043d\u0442\u044b<\/h1><div class='special-heading-border'><div class='special-heading-inner-border' style='border-color:#011642'><\/div><\/div><\/div><br \/>\n<section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock  '   itemprop=\"text\" ><h2>\u041f\u043e\u0441\u043b\u0435\u0434\u043d\u0438\u0435, \u0437\u0430\u0441\u043b\u0443\u0436\u0438\u0432\u0430\u044e\u0449\u0438\u0435 \u0432\u043d\u0438\u043c\u0430\u043d\u0438\u044f \u043f\u0443\u0431\u043b\u0438\u043a\u0430\u0446\u0438\u0438<\/h2>\n<\/div><\/section><\/p><\/div><div class='flex_column_table av-equal-height-column-flextable -flextable' ><div class=\"flex_column av_one_half  flex_column_table_cell av-equal-height-column av-align-top av-zero-column-padding first  avia-builder-el-4  el_after_av_one_full  el_before_av_one_half  column-top-margin\" style='border-radius:0px; '><section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock  '   itemprop=\"text\" ><h3>\u041a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u044f<\/h3>\n<p>Anderson, WJ, Short, PM, Jabbal, S, Lipworth, BJ.\u00a0<span class=\"bold-blue\"><strong>Inhaled corticosteroid dose response in asthma.\u00a0 Should we measure inflammation?<\/strong><\/span>\u00a0Ann Allergy Asthma Immunol 2017, 118, 179e185<\/p>\n<p>Coumou H, Westerhof GA, de Nijs SB, et al.\u00a0<span class=\"bold-blue\">Predictors of accelerated decline in lung function in adult-onset asthma.<\/span>\u00a0Eur Respir J. 2018; 51: 1701785.<\/p>\n<p>Hanania N, Massanari M, Jain N.\u00a0<span class=\"bold-blue\">Measurement of fractional exhaled nitric oxide in real-world clinical practice alters asthma treatment decisions.<\/span>\u00a0Ann Allergy Asthma Immunol. 2018;120: 414\u2013418<\/p>\n<p>Karrasch S, Linde K, R\u00fccker G, et al.\u00a0<span class=\"bold-blue\">Accuracy of FENO for diagnosing asthma: a systematic review.<\/span>\u00a0Thorax 2017; 72:109\u2013116<\/p>\n<p>Morten M, Collison A, Murphy VE, et al.\u00a0<span class=\"bold-blue\">Managing Asthma in Pregnancy (MAP) trial: FeNO levels and childhood asthma.<\/span>\u00a0J Allergy Clin Immunol 2018; doi: 10.1016\/j.jaci.2018.02.039.<\/p>\n<p>Price D, Buhl R, Chan A, et al.<span class=\"bold-blue\">\u00a0Fractional exhaled nitric oxide as a predictor of response to inhaled corticosteroids in patients with non-specific respiratory symptoms and insignificant bronchodilator reversibility: a randomised controlled trial.<\/span>\u00a0Lancet Resp Med 2017; Published Online November 3, 2017.\u00a0<span class=\"external\"><a class=\"external\" href=\"http:\/\/dx.doi.org\/10.1016\/S2213-2600(17)30424-1\" target=\"_blank\" rel=\"noopener noreferrer\">http:\/\/dx.doi.org\/10.1016\/S2213-2600(17)30424-1<\/a><\/span><\/p>\n<h3>\u042d\u043a\u043e\u043d\u043e\u043c\u0438\u0447\u0435\u0441\u043a\u0430\u044f \u044d\u0444\u0444\u0435\u043a\u0442\u0438\u0432\u043d\u043e\u0441\u0442\u044c<\/h3>\n<p>Arnold RJ, Massanari M, Lee TA, Brooks E.\u00a0<span class=\"bold-blue\">A Review of the Utility and\u00a0<\/span>Cost Effectiveness<span class=\"bold-blue\">\u00a0of Monitoring Fractional Exhaled Nitric Oxide (FeNO) in Asthma Management.\u00a0<\/span>Manag Care. 2018 Jul;27(7):34-41.<\/p>\n<p>Arnold RJG, Layton A, Massanari M.\u00a0<span class=\"bold-blue\">Cost impact of monitoring exhaled nitric oxide in asthma management.<\/span>\u00a0Allergy Asthma Proc. 2018 Aug 13. doi: 10.2500\/aap.2018.39.4165. [Epub ahead of print]<\/p>\n<p>Brooks EA, Massanari M.\u00a0<span class=\"bold-blue\">Cost-Effectiveness Analysis of Monitoring Fractional Exhaled Nitric Oxide (FeNO) in the Management of Asthma.<\/span>\u00a0Manag Care. 2018 Jul;27(7):42-48.<\/p>\n<\/div><\/section><\/div><div class='av-flex-placeholder'><\/div><div class=\"flex_column av_one_half  flex_column_table_cell av-equal-height-column av-align-top av-zero-column-padding   avia-builder-el-6  el_after_av_one_half  avia-builder-el-last  column-top-margin\" style='border-radius:0px; '><section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock  '   itemprop=\"text\" ><h3>\u0414\u043e\u043a\u0430\u0437\u0430\u0442\u0435\u043b\u044c\u043d\u0430\u044f \u0431\u0430\u0437\u0430<\/h3>\n<p>Petsky HL, Cates CJ, Kew KM, Chang AB.\u00a0<span class=\"bold-blue\">Tailoring asthma treatment on eosinophilic markers (exhaled nitric oxide or sputum eosinophils): a systematic review and meta-analysis.<\/span>\u00a0Thorax. 2018 Jun 1. pii: thoraxjnl-2018-211540. doi: 10.1136\/thoraxjnl-2018-211540.<\/p>\n<p>Pavord ID, Beasley R, Agusti A, et al.\u00a0<span class=\"bold-blue\">The Lancet Commissions. After Asthma: Refining Airways Diseases. Lancet 2017.<\/span>\u00a0Published Online September 11, 2017.\u00a0<span class=\"external\"><a class=\"external\" href=\"http:\/\/dx.doi.org\/10.1016\/S0140-6736(17)30879-6\" target=\"_blank\" rel=\"noopener noreferrer\">http:\/\/dx.doi.org\/10.1016\/S0140-6736(17)30879-6<\/a><\/span><\/p>\n<p>Petsky HL, Kew KM, Turner C, Chang AB.<span class=\"bold-blue\">\u00a0Exhaled nitric oxide levels to guide treatment for adults with asthma.<\/span>\u00a0Cochrane Database of Systematic Reviews. 2016, Issue 9. Art. No.: CD011440.<\/p>\n<p>Petsky HL, Kew KM, Chang AB.\u00a0<span class=\"bold-blue\">Exhaled nitric oxide levels to guide treatment for children with asthma.<\/span>\u00a0Cochrane Database of Systematic Reviews. 2016, Issue 11. Art. No.: CD011439.<\/p>\n<p>Wang Z, Pianosi P, Keogh K, et al.\u00a0<span class=\"bold-blue\">The Clinical Utility of Fractional Exhaled Nitric Oxide (FeNO) in Asthma Management.<\/span>\u00a0Comparative Effectiveness Review No. 197 (Prepared by the Mayo Clinic Evidence-based Practice Center under Contract No. 290-2015-00013-I). AHRQ Publication No.17(18)-EHC030-EF. Rockville, MD: Agency for Healthcare Research and Quality. December 2017.\u00a0<span class=\"external\"><a class=\"external\" href=\"https:\/\/effectivehealthcare.ahrq.gov\/sites\/default\/files\/pdf\/cer-197-fractional-exhaled-nitric-oxide_0.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">https:\/\/effectivehealthcare.ahrq.gov\/sites\/default\/files\/pdf\/cer-197-fractional-exhaled-nitric-oxide_0.pdf<\/a><\/span>. Accessed January 3, 2018.<\/p>\n<h3>\u0413\u0430\u0439\u0434\u043b\u0430\u0439\u043d\u044b<\/h3>\n<p><span class=\"bold-blue\">GINA-Global Strategy for Asthma Management and Prevention, Global Initiative for Asthma (GINA).<\/span>\u00a02018. Full text available online at: www.ginasthma.org. Accessed on April 10, 2018.<\/p>\n<p><span class=\"bold-blue\">NICE. National Institute for Health and Clinical Excellence. Asthma: diagnosis, monitoring and chronic asthma management NICE guideline [NG80].<\/span>\u00a0November 2017. Available at:\u00a0<span class=\"external\"><a href=\"https:\/\/www.nice.org.uk\/guidance\/ng80\" target=\"_blank\" rel=\"noopener noreferrer\">https:\/\/www.nice.org.uk\/guidance\/ng80<\/a><\/span>. Accessed February 21, 2018.<\/p>\n<\/div><\/section><\/div><\/div><!--close column table wrapper. Autoclose: 1 -->\n<\/div><\/div><\/main><!-- close content main element --><\/div><\/div><div id='after_section_1'  class='main_color av_default_container_wrap container_wrap sidebar_right' style=' '  ><div class='container' ><div class='template-page content  av-content-small alpha units'><div class='post-entry post-entry-type-page post-entry-678'><div class='entry-content-wrapper clearfix'>\n<div class=\"flex_column av_one_full  flex_column_div av-zero-column-padding first  avia-builder-el-8  el_after_av_section  el_before_av_one_full  avia-builder-el-first  \" style='border-radius:0px; '><section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock  '   itemprop=\"text\" ><p style=\"font-weight: 400;\"><strong>\u0413\u043b\u043e\u0431\u0430\u043b\u044c\u043d\u0430\u044f \u0440\u0430\u0441\u043f\u0440\u043e\u0441\u0442\u0440\u0430\u043d\u0435\u043d\u043d\u043e\u0441\u0442\u044c \u0430\u0441\u0442\u043c\u044b \u0443 \u0432\u0437\u0440\u043e\u0441\u043b\u044b\u0445: \u0440\u0435\u0437\u0443\u043b\u044c\u0442\u0430\u0442\u044b \u043f\u0435\u0440\u0435\u043a\u0440\u0435\u0441\u0442\u043d\u043e\u0433\u043e \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u044f \u0441\u043e\u0441\u0442\u043e\u044f\u043d\u0438\u044f \u0437\u0434\u043e\u0440\u043e\u0432\u044c\u044f \u0432 \u043c\u0438\u0440\u0435<\/strong><\/p>\n<p style=\"font-weight: 400;\">Teresa To1,2,3,9*, Sanja Stanojevic1, Ginette Moores1,4, Andrea S Gershon1,2,3,5, Eric D Bateman6, Alvaro A Cruz7 and\u00a0Louis-Philippe Boulet<\/p>\n<p style=\"font-weight: 400;\">To et al. BMC Public Health 2012, 12:204\u00a0http:\/\/www.biomedcentral.com\/1471-2458\/12\/204<\/p>\n<p style=\"font-weight: 400;\"><strong><a href=\"https:\/\/niox.com.ua\/wp-content\/uploads\/2020\/01\/1471-2458-12-204-1.pdf\">\u0421\u043a\u0430\u0447\u0430\u0442\u044c<\/a><\/strong><\/p>\n<\/div><\/section><br \/>\n<div  style='height:30px' class='hr hr-invisible   avia-builder-el-10  el_after_av_textblock  el_before_av_textblock '><span class='hr-inner ' ><span class='hr-inner-style'><\/span><\/span><\/div><br \/>\n<section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock  '   itemprop=\"text\" ><p style=\"font-weight: 400;\"><strong>\u0412\u0435\u0434\u0435\u043d\u0438\u0435 \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432 \u0441\u00a0\u0442\u044f\u0436\u0435\u043b\u043e\u0439 \u0430\u0441\u0442\u043c\u043e\u0439: \u0440\u0443\u043a\u043e\u0432\u043e\u0434\u0441\u0442\u0432\u043e \u0415\u0432\u0440\u043e\u043f\u0435\u0439\u0441\u043a\u043e\u0433\u043e \u0440\u0435\u0441\u043f\u0438\u0440\u0430\u0442\u043e\u0440\u043d\u043e\u0433\u043e \u043e\u0431\u0449\u0435\u0441\u0442\u0432\u0430 \/ \u0410\u043c\u0435\u0440\u0438\u043a\u0430\u043d\u0441\u043a\u043e\u0433\u043e \u0442\u043e\u0440\u0430\u043a\u0430\u043b\u044c\u043d\u043e\u0433\u043e \u043e\u0431\u0449\u0435\u0441\u0442\u0432\u0430.<\/strong><\/p>\n<p style=\"font-weight: 400;\">Holguin F, Cardet JC, Chung KF et all\u00a0Eur\u00a0Respir J. 2020 Jan 2;55(1). pii: 1900588. doi: 10.1183\/13993003.00588-2019. Print\u00a02020 Jan. PubMed PMID: 31558662.<\/p>\n<p style=\"font-weight: 400;\"><strong><a href=\"https:\/\/niox.com.ua\/wp-content\/uploads\/2020\/01\/13993003.00588-2019.full_.pdf\">\u0421\u043a\u0430\u0447\u0430\u0442\u044c<\/a><\/strong><\/p>\n<\/div><\/section><br \/>\n<div  style='height:30px' class='hr hr-invisible   avia-builder-el-12  el_after_av_textblock  el_before_av_textblock '><span class='hr-inner ' ><span class='hr-inner-style'><\/span><\/span><\/div><br \/>\n<section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock  '   itemprop=\"text\" ><p style=\"font-weight: 400;\"><strong>\u0414\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u043a\u0430 \u0430\u0441\u0442\u043c\u044b \u0443 \u0434\u0435\u0442\u0435\u0439: \u0432\u043a\u043b\u0430\u0434 \u0434\u0435\u0442\u0430\u043b\u044c\u043d\u043e\u0433\u043e \u0430\u043d\u0430\u043c\u043d\u0435\u0437\u0430 \u0438 \u0440\u0435\u0437\u0443\u043b\u044c\u0442\u0430\u0442\u043e\u0432\u00a0<\/strong><strong>\u0442\u0435\u0441\u0442\u043e\u0432.<\/strong><\/p>\n<p style=\"font-weight: 400;\">de Jong CCM, Pedersen ESL, Mozun R, Goutaki M, Trachsel D, Barben J, Kuehni\u00a0CE.\u00a0. Eur Respir J. 2019 Dec 4;54(6). pii: 1901326. doi:\u00a010.1183\/13993003.01326-2019. Print 2019 Dec. PubMed PMID: 31515409.<\/p>\n<p><strong><a href=\"https:\/\/niox.com.ua\/wp-content\/uploads\/2020\/01\/ERJ-2019-Utilidad-de-FENO-en-Asma-en-ni\u00f1os.pdf\">\u0421\u043a\u0430\u0447\u0430\u0442\u044c<\/a><\/strong><\/p>\n<\/div><\/section><br \/>\n<div  style='height:30px' class='hr hr-invisible   avia-builder-el-14  el_after_av_textblock  el_before_av_textblock '><span class='hr-inner ' ><span class='hr-inner-style'><\/span><\/span><\/div><br \/>\n<section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock  '   itemprop=\"text\" ><p><strong>\u0412\u0438\u043c\u0456\u0440\u044e\u0432\u0430\u043d\u043d\u044f \u0444\u0440\u0430\u043a\u0446\u0456\u0457 \u043e\u043a\u0441\u0438\u0434\u0443 \u0430\u0437\u043e\u0442\u0443 \u0432 \u043f\u043e\u0432\u0456\u0442\u0440\u0456, \u0449\u043e \u0432\u0438\u0434\u0438\u0445\u0430\u0454\u0442\u044c\u0441\u044f,\u00a0 \u0434\u043b\u044f \u043a\u043e\u0440\u0435\u0433\u0443\u0432\u0430\u043d\u043d\u044f \u043b\u0456\u043a\u0443\u0432\u0430\u043d\u043d\u044f \u043f\u0430\u0446\u0456\u0454\u043d\u0442\u0456\u0432, \u0445\u0432\u043e\u0440\u0438\u0445 \u043d\u0430 \u0430\u0441\u0442\u043c\u0443: \u0441\u0438\u0441\u0442\u0435\u043c\u0430\u0442\u0438\u0447\u043d\u0438\u0439 \u043e\u0433\u043b\u044f\u0434 \u0442\u0430 \u043c\u0435\u0442\u0430\u0430\u043d\u0430\u043b\u0456\u0437 \u0456\u043d\u0434\u0438\u0432\u0456\u0434\u0443\u0430\u043b\u044c\u043d\u0438\u0445 \u0434\u0430\u043d\u0438\u0445 \u043f\u0430\u0446\u0456\u0454\u043d\u0442\u0456\u0432<\/strong><\/p>\n<p>Wang K, Verbakel JY, Oke J, et al.\u00a0 Eur Respir J. 2020;55(5):1902150. Published 2020 May 21. doi:10.1183\/13993003.02150-2019<\/p>\n<p>\u0420\u0415\u0417\u042e\u041c\u0415<br \/>\n\u0417\u0430\u0433\u0430\u043b\u044c\u043d\u0430 \u0456\u043d\u0444\u043e\u0440\u043c\u0430\u0446\u0456\u044f: \u0412\u0438\u0441\u043e\u043a\u0438\u0439 \u0440\u0456\u0432\u0435\u043d\u044c \u0444\u0440\u0430\u043a\u0446\u0456\u0457 \u043e\u043a\u0441\u0438\u0434\u0443 \u0430\u0437\u043e\u0442\u0443 \u0432 \u043f\u043e\u0432\u0456\u0442\u0440\u0456, \u0449\u043e \u0432\u0438\u0434\u0438\u0445\u0430\u0454\u0442\u044c\u0441\u044f (FENO), \u043f\u043e\u0432\u2019\u044f\u0437\u0443\u044e\u0442\u044c \u0437 \u0432\u0438\u0449\u0438\u043c \u0440\u0438\u0437\u0438\u043a\u043e\u043c \u0437\u0430\u0433\u043e\u0441\u0442\u0440\u0435\u043d\u043d\u044f \u0430\u0441\u0442\u043c\u0438. \u041f\u0440\u043e\u0442\u0435, \u043d\u0435 \u0432\u0456\u0434\u043e\u043c\u043e, \u044f\u043a \u043c\u043e\u0436\u043d\u0430 \u0432\u0438\u043a\u043e\u0440\u0438\u0441\u0442\u043e\u0432\u0443\u0432\u0430\u0442\u0438 FENO \u0434\u043b\u044f \u0431\u0435\u0437\u043f\u0435\u0447\u043d\u043e\u0433\u043e \u0437\u043c\u0435\u043d\u0448\u0435\u043d\u043d\u044f \u0434\u043e\u0437 \u0456\u043d\u0433\u0430\u043b\u044f\u0446\u0456\u0439\u043d\u043e\u0433\u043e \u043a\u043e\u0440\u0442\u0438\u043a\u043e\u0441\u0442\u0435\u0440\u043e\u0457\u0434\u0430 (\u0406\u041a\u0421) \u0443 \u0445\u0432\u043e\u0440\u0438\u0445 \u043d\u0430 \u0430\u0441\u0442\u043c\u0443. \u0412 \u0446\u044c\u043e\u043c\u0443 \u0434\u043e\u0441\u043b\u0456\u0434\u0436\u0435\u043d\u043d\u0456 \u043e\u0446\u0456\u043d\u044e\u0454\u0442\u044c\u0441\u044f \u043c\u043e\u0436\u043b\u0438\u0432\u0456\u0441\u0442\u044c FENO \u043a\u0435\u0440\u0443\u0432\u0430\u0442\u0438 \u0437\u043c\u0435\u043d\u0448\u0435\u043d\u043d\u044f\u043c \u0437\u0430\u0441\u0442\u043e\u0441\u0443\u0432\u0430\u043d\u043d\u044f ICS.<br \/>\n\u041c\u0435\u0442\u043e\u0434\u0438: \u0421\u0438\u0441\u0442\u0435\u043c\u0430\u0442\u0438\u0447\u043d\u0438\u0439 \u043f\u043e\u0448\u0443\u043a \u0432 \u0435\u043b\u0435\u043a\u0442\u0440\u043e\u043d\u043d\u0438\u0445 \u0431\u0430\u0437\u0430\u0445 \u0434\u0430\u043d\u0438\u0445 \u0434\u043e\u0437\u0432\u043e\u043b\u0438\u0432 \u0432\u0438\u044f\u0432\u0438\u0442\u0438 \u043f\u0440\u043e\u0441\u043f\u0435\u043a\u0442\u0438\u0432\u043d\u0456 \u0435\u043a\u0441\u043f\u0435\u0440\u0438\u043c\u0435\u043d\u0442\u0430\u043b\u044c\u043d\u0456 \u0434\u043e\u0441\u043b\u0456\u0434\u0436\u0435\u043d\u043d\u044f \u0442\u0430 \u0440\u0430\u043d\u0434\u043e\u043c\u0456\u0437\u043e\u0432\u0430\u043d\u0456 \u043a\u043e\u043d\u0442\u0440\u043e\u043b\u044c\u043e\u0432\u0430\u043d\u0456 \u0441\u043f\u0440\u043e\u0431\u0438, \u0449\u043e \u0437\u0430\u043b\u0443\u0447\u0430\u043b\u0438 \u0443\u0447\u0430\u0441\u043d\u0438\u043a\u0456\u0432 \u0432\u0456\u043a\u043e\u043c \u2a7e12 \u0440\u043e\u043a\u0456\u0432 \u0437 \u043b\u0435\u0433\u043a\u043e\u044e \u0442\u0430 \u0441\u0435\u0440\u0435\u0434\u043d\u044c\u043e\u044e \u0444\u043e\u0440\u043c\u0430\u043c\u0438 \u0430\u0441\u0442\u043c\u0438 \u0442\u0430 \u0432\u0438\u043c\u0456\u0440\u044e\u0432\u0430\u043b\u0438 FENO \u043f\u0435\u0440\u0435\u0434 \u0437\u043c\u0435\u043d\u0448\u0435\u043d\u043d\u044f\u043c \u0434\u043e\u0437 \u0406\u041a\u0421. \u041c\u0438 \u0437\u0430\u0441\u0442\u043e\u0441\u0443\u0432\u0430\u043b\u0438 \u0431\u0430\u0433\u0430\u0442\u043e\u0440\u0456\u0432\u043d\u0435\u0432\u0443 \u043b\u043e\u0433\u0456\u0441\u0442\u0438\u0447\u043d\u0443 \u0440\u0435\u0433\u0440\u0435\u0441\u0456\u044e \u0437\u0456 \u0437\u043c\u0456\u0448\u0430\u043d\u0438\u043c\u0438 \u0435\u0444\u0435\u043a\u0442\u0430\u043c\u0438 \u0432\u0456\u0434\u043d\u043e\u0441\u043d\u043e \u0440\u0456\u0437\u043a\u0438\u0445 \u0437\u0430\u0433\u043e\u0441\u0442\u0440\u0435\u043d\u044c \u0442\u0430 \u043e\u0446\u0456\u043d\u0438\u043b\u0438 \u0440\u0438\u0437\u0438\u043a \u0437\u0430\u0433\u043e\u0441\u0442\u0440\u0435\u043d\u043d\u044f \u0443 \u043a\u043e\u0436\u043d\u043e\u0433\u043e \u043f\u0430\u0446\u0456\u0454\u043d\u0442\u0430 \u0437\u0430 \u0434\u043e\u043f\u043e\u043c\u043e\u0433\u043e\u044e \u0441\u0432\u043e\u0454\u0457 \u043c\u043e\u0434\u0435\u043b\u0456 \u043b\u043e\u0433\u0456\u0441\u0442\u0438\u0447\u043d\u043e\u0457 \u0440\u0435\u0433\u0440\u0435\u0441\u0456\u0457.<br \/>\n\u0420\u0435\u0437\u0443\u043b\u044c\u0442\u0430\u0442\u0438: \u041c\u0438 \u0432\u043a\u043b\u044e\u0447\u0438\u043b\u0438 \u0434\u0430\u043d\u0456 \u0441\u0435\u043c\u0438 \u0437 \u0432\u043e\u0441\u044c\u043c\u0438 \u0432\u0456\u0434\u043f\u043e\u0432\u0456\u0434\u043d\u0438\u0445 \u043d\u0430\u0448\u0438\u043c \u043a\u0440\u0438\u0442\u0435\u0440\u0456\u044f\u043c \u0434\u043e\u0441\u043b\u0456\u0434\u0436\u0435\u043d\u044c, \u0449\u043e \u043f\u0440\u0435\u0434\u0441\u0442\u0430\u0432\u043b\u044f\u043b\u0438 384 \u0443\u0447\u0430\u0441\u043d\u0438\u043a\u0456\u0432. \u0412 \u0447\u043e\u0442\u0438\u0440\u044c\u043e\u0445 \u0434\u043e\u0441\u043b\u0456\u0434\u0436\u0435\u043d\u043d\u044f\u0445 \u0434\u043e\u0437\u0438 \u0406\u041a\u0421 \u0431\u0443\u043b\u0438 \u0437\u043c\u0435\u043d\u0448\u0435\u043d\u0456 \u0432\u0434\u0432\u0456\u0447\u0456, \u0430 \u0432 \u0442\u0440\u044c\u043e\u0445 \u2013 \u0432\u0438\u043b\u0443\u0447\u0435\u043d\u0456. \u0411\u0443\u0432 \u0432\u0438\u0437\u043d\u0430\u0447\u0435\u043d\u0438\u0439 \u0431\u0430\u0437\u043e\u0432\u0438\u0439 \u0440\u0456\u0432\u0435\u043d\u044c FENO \u2a7e50 ppb, \u0449\u043e \u0430\u0441\u043e\u0446\u0456\u044e\u0432\u0430\u0432\u0441\u044f \u0437 \u043f\u0456\u0434\u0432\u0438\u0449\u0435\u043d\u0438\u043c \u0440\u0438\u0437\u0438\u043a\u043e\u043c \u0437\u0430\u0433\u043e\u0441\u0442\u0440\u0435\u043d\u043d\u044f (\u0437\u0430\u0433\u0430\u043b\u044c\u043d\u0438\u0439 \u041a\u0428 3.14, 95% \u0414\u0406 1.41\u20137.00, p=0.005; \u0441\u043a\u043e\u0440\u0438\u0433\u043e\u0432\u0430\u043d\u0438\u0439 \u041a\u0428 3.08, 95% \u0414\u0406 1.36\u20136.98, p=0.007) \u0442\u0430 \u0432\u0456\u0434\u043f\u043e\u0432\u0456\u0434\u0430\u0432 \u043e\u0440\u0456\u0454\u043d\u0442\u043e\u0432\u043d\u043e\u043c\u0443 \u043f\u043e\u0440\u043e\u0433\u0443 \u0440\u0438\u0437\u0438\u043a\u0443 \u0437\u0430\u0433\u043e\u0441\u0442\u0440\u0435\u043d\u043d\u044f 15%. \u0417\u043c\u0435\u043d\u0448\u0435\u043d\u043d\u044f \u0406\u041a\u0421 \u043f\u0440\u0438 \u043e\u0440\u0456\u0454\u043d\u0442\u043e\u0432\u043d\u043e\u043c\u0443 \u043f\u043e\u0440\u043e\u0433\u0443 \u0440\u0438\u0437\u0438\u043a\u0443 \u0437\u0430\u0433\u043e\u0441\u0442\u0440\u0435\u043d\u043d\u044f &lt;15% \u043f\u0440\u043e\u0442\u0438 &lt;10% \u043f\u0440\u0438\u0437\u0432\u0435\u043b\u043e \u0431 \u0434\u043e \u0437\u043c\u0435\u043d\u0448\u0435\u043d\u043d\u044f \u043a\u0456\u043b\u044c\u043a\u043e\u0441\u0442\u0456 \u043f\u0430\u0446\u0456\u0454\u043d\u0442\u0456\u0432, \u044f\u043a\u0456 \u0437\u0431\u0435\u0440\u0435\u0433\u043b\u0438 \u0431 \u0442\u0456 \u0441\u0430\u043c\u0456 \u0434\u043e\u0437\u0438 \u0406\u041a\u0421 (40 (10.4%) \u0437 384 \u043f\u0440\u043e\u0442\u0438 141 (36.7%) \u0437 384), \u0430\u043b\u0435 \u043f\u0440\u0438 \u0430\u043d\u0430\u043b\u043e\u0433\u0456\u0447\u043d\u0438\u0445 \u043f\u0440\u043e\u043f\u043e\u0440\u0446\u0456\u044f\u0445 \u043f\u0430\u0446\u0456\u0454\u043d\u0442\u0456\u0432, \u0449\u043e \u0443\u043d\u0438\u043a\u043d\u0443\u043b\u0438 \u0437\u0430\u0433\u043e\u0441\u0442\u0440\u0435\u043d\u043d\u044f (222 (91.4%) \u0437 243, 95% \u0414\u0406 87.1\u201394.6% \u043f\u0440\u043e\u0442\u0438 311 (90.4%) \u0437 344, 95% \u0414\u0406 86.8\u201393.3%).<br \/>\n\u0412\u0438\u0441\u043d\u043e\u0432\u043e\u043a: \u0423 \u043f\u0430\u0446\u0456\u0454\u043d\u0442\u0456\u0432 \u0437 \u043b\u0435\u0433\u043a\u043e\u044e \u0442\u0430 \u0441\u0435\u0440\u0435\u0434\u043d\u044c\u043e\u044e \u0444\u043e\u0440\u043c\u0430\u043c\u0438 \u0430\u0441\u0442\u043c\u0438 \u043f\u043e\u0441\u0442\u0443\u043f\u043e\u0432\u0435 \u0437\u043c\u0435\u043d\u0448\u0435\u043d\u043d\u044f \u0406\u041a\u0421 \u043f\u0440\u0438 \u0440\u0456\u0432\u043d\u0456 FENO &lt;50 ppb \u043c\u043e\u0436\u0435 \u0434\u043e\u043f\u043e\u043c\u043e\u0433\u0442\u0438 \u0441\u043a\u043e\u0440\u043e\u0442\u0438\u0442\u0438 \u0437\u0430\u0441\u0442\u043e\u0441\u0443\u0432\u0430\u043d\u043d\u044f \u0406\u041a\u0421 \u0431\u0435\u0437 \u0440\u0438\u0437\u0438\u043a\u0443 \u0432\u0438\u043d\u0438\u043a\u043d\u0435\u043d\u043d\u044f \u0437\u0430\u0433\u043e\u0441\u0442\u0440\u0435\u043d\u044c. \u041c\u0430\u0439\u0431\u0443\u0442\u043d\u0456 \u0434\u043e\u0441\u043b\u0456\u0434\u0436\u0435\u043d\u043d\u044f \u043f\u043e\u0432\u0438\u043d\u043d\u0456 \u043f\u0456\u0434\u0442\u0432\u0435\u0440\u0434\u0438\u0442\u0438 \u0446\u0456 \u0440\u0435\u0437\u0443\u043b\u044c\u0442\u0430\u0442\u0438 \u043d\u0430 \u043e\u0441\u043d\u043e\u0432\u0456 \u0434\u043e\u0441\u043b\u0456\u0434\u0436\u0435\u043d\u043d\u044f \u0431\u0456\u043b\u044c\u0448\u043e\u0457 \u043a\u0456\u043b\u044c\u043a\u043e\u0441\u0442\u0456 \u043f\u0430\u0446\u0456\u0454\u043d\u0442\u0456\u0432.<\/p>\n<p><strong><a href=\"https:\/\/niox.com.ua\/wp-content\/uploads\/2020\/08\/Wang-2020.pdf\">\u0421\u043a\u0430\u0447\u0430\u0442\u044c<\/a><\/strong><\/p>\n<\/div><\/section><br \/>\n<div  style='height:30px' class='hr hr-invisible   avia-builder-el-16  el_after_av_textblock  el_before_av_textblock '><span class='hr-inner ' ><span class='hr-inner-style'><\/span><\/span><\/div><br \/>\n<section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock  '   itemprop=\"text\" ><p style=\"font-weight: 400;\"><strong>FENO as a biomarker guide for inhaled corticosteroid step down in patients with mild-to-moderate well-controlled asthma.<\/strong><\/p>\n<p style=\"font-weight: 400;\">Dinh-Xuan AT, Brusselle G.\u00a0 Eur Respir J. 2020;55(5):2001319. Published 2020 May 21. doi:10.1183\/13993003.01319-2020<\/p>\n<p><strong><a href=\"https:\/\/niox.com.ua\/wp-content\/uploads\/2020\/08\/Editorial-ERJ-2020.pdf\">\u0421\u043a\u0430\u0447\u0430\u0442\u044c<\/a><\/strong><\/p>\n<\/div><\/section><\/p><\/div><div class=\"flex_column av_one_full  flex_column_div av-zero-column-padding first  avia-builder-el-18  el_after_av_one_full  el_before_av_one_fifth  column-top-margin\" style='border-radius:0px; '><section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock  '   itemprop=\"text\" ><h2>Whitepapers<\/h2>\n<\/div><\/section><\/div><\/p>\n<div class=\"flex_column av_one_fifth  flex_column_div av-zero-column-padding first  avia-builder-el-20  el_after_av_one_full  el_before_av_four_fifth  column-top-margin\" style='border-radius:0px; '><p><section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock  '   itemprop=\"text\" ><p><img decoding=\"async\" loading=\"lazy\" class=\"size-full wp-image-679 aligncenter\" src=\"https:\/\/niox.com.ua\/wp-content\/uploads\/2019\/11\/clinical-value-monitoring-exhaled-nitric-oxide-in-asthma-management.png\" alt=\"\" width=\"165\" height=\"213\" \/><\/p>\n<\/div><\/section><br \/>\n<div  class='avia-button-wrap avia-button-center  avia-builder-el-22  el_after_av_textblock  avia-builder-el-last ' ><a href='https:\/\/niox.com.ua\/wp-content\/uploads\/2019\/11\/clinical-value-monitoring-exhaled-nitric-oxide-in-asthma-management.pdf'  class='avia-button   avia-icon_select-yes-left-icon avia-color-orange avia-size-small avia-position-center '   ><span class='avia_button_icon avia_button_icon_left ' aria-hidden='true' data-av_icon='\ue8b0' data-av_iconfont='entypo-fontello'><\/span><span class='avia_iconbox_title' >\u0421\u043a\u0430\u0447\u0430\u0442\u044c<\/span><\/a><\/div><\/p><\/div>\n<div class=\"flex_column av_four_fifth  flex_column_div av-zero-column-padding   avia-builder-el-23  el_after_av_one_fifth  el_before_av_section  avia-builder-el-last  column-top-margin\" style='border-radius:0px; '><section class=\"av_textblock_section \"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock  '   itemprop=\"text\" ><h3>Circassia White Paper. \u0420\u0435\u0437\u044e\u043c\u0435 \u0444\u0430\u043a\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0445 \u0434\u0430\u043d\u043d\u044b\u0445, \u043f\u043e\u0434\u0442\u0432\u0435\u0440\u0436\u0434\u0430\u044e\u0449\u0438\u0445 \u043a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u0443\u044e \u0446\u0435\u043d\u043d\u043e\u0441\u0442\u044c \u043c\u043e\u043d\u0438\u0442\u043e\u0440\u0438\u043d\u0433\u0430 \u043e\u043a\u0441\u0438\u0434\u0430 \u0430\u0437\u043e\u0442\u0430 \u0432 \u0432\u044b\u0434\u044b\u0445\u0430\u0435\u043c\u043e\u043c \u0432\u043e\u0437\u0434\u0443\u0445\u0435 (FeNO) \u0432 \u043b\u0435\u0447\u0435\u043d\u0438\u0438 \u0430\u0441\u0442\u043c\u044b. Circassia Pharmaceuticals, Inc., \u043c\u0430\u0439 2018 \u0433.<\/h3>\n<p>\u041b\u0435\u0447\u0435\u043d\u0438\u0435 \u0430\u0441\u0442\u043c\u044b \u043f\u043e\u0434\u0434\u0435\u0440\u0436\u0438\u0432\u0430\u0435\u0442\u0441\u044f \u043d\u0430\u0446\u0438\u043e\u043d\u0430\u043b\u044c\u043d\u044b\u043c\u0438 \u0440\u0443\u043a\u043e\u0432\u043e\u0434\u0441\u0442\u0432\u0430\u043c\u0438, \u043a\u043e\u0442\u043e\u0440\u044b\u0435 \u0431\u044b\u043b\u0438 \u0438\u0437\u043d\u0430\u0447\u0430\u043b\u044c\u043d\u043e \u0441\u043e\u0437\u0434\u0430\u043d\u044b, \u0447\u0442\u043e\u0431\u044b \u043f\u043e\u0434\u0447\u0435\u0440\u043a\u043d\u0443\u0442\u044c \u0432\u0430\u0436\u043d\u043e\u0441\u0442\u044c \u043b\u0435\u0447\u0435\u043d\u0438\u044f \u0432\u043e\u0441\u043f\u0430\u043b\u0438\u0442\u0435\u043b\u044c\u043d\u043e\u0433\u043e \u0445\u0430\u0440\u0430\u043a\u0442\u0435\u0440\u0430 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u044f \u0434\u043b\u044f \u0443\u043b\u0443\u0447\u0448\u0435\u043d\u0438\u044f \u0440\u0435\u0437\u0443\u043b\u044c\u0442\u0430\u0442\u043e\u0432 \u043b\u0435\u0447\u0435\u043d\u0438\u044f \u043f\u0430\u0446\u0438\u0435\u043d\u0442\u043e\u0432 (NHLBI 1991). \u0421\u0435\u0433\u043e\u0434\u043d\u044f FeNO (\u0444\u0440\u0430\u043a\u0446\u0438\u043e\u043d\u043d\u043e \u0432\u044b\u0434\u044b\u0445\u0430\u0435\u043c\u044b\u0439 \u043e\u043a\u0441\u0438\u0434 \u0430\u0437\u043e\u0442\u0430) \u044f\u0432\u043b\u044f\u0435\u0442\u0441\u044f \u0445\u043e\u0440\u043e\u0448\u043e \u0443\u0441\u0442\u0430\u043d\u043e\u0432\u043b\u0435\u043d\u043d\u044b\u043c, \u043f\u0440\u043e\u0432\u0435\u0440\u0435\u043d\u043d\u044b\u043c \u0438 \u0441\u043f\u0435\u0446\u0438\u0444\u0438\u0447\u0435\u0441\u043a\u0438\u043c \u0431\u0438\u043e\u043c\u0430\u0440\u043a\u0435\u0440\u043e\u043c \u0432\u043e\u0441\u043f\u0430\u043b\u0435\u043d\u0438\u044f \u0434\u044b\u0445\u0430\u0442\u0435\u043b\u044c\u043d\u044b\u0445 \u043f\u0443\u0442\u0435\u0439, \u0432\u044b\u0437\u0432\u0430\u043d\u043d\u043e\u0433\u043e \u0422h2, \u043f\u0440\u0438 \u0430\u0441\u0442\u043c\u0435, \u0441\u043f\u0443\u0441\u0442\u044f 20 \u043b\u0435\u0442 \u043f\u043e\u0441\u043b\u0435 \u043f\u043e\u043b\u0443\u0447\u0435\u043d\u0438\u044f \u041d\u043e\u0431\u0435\u043b\u0435\u0432\u0441\u043a\u043e\u0439 \u043f\u0440\u0435\u043c\u0438\u0438 \u0432 1998 \u0433. \u0437\u0430 \u043f\u043e\u043d\u0438\u043c\u0430\u043d\u0438\u0435 \u0432\u0430\u0436\u043d\u043e\u0441\u0442\u0438 \u043e\u043a\u0441\u0438\u0434\u0430 \u0430\u0437\u043e\u0442\u0430 \u0432 \u0441\u0435\u0440\u0434\u0435\u0447\u043d\u043e-\u0441\u043e\u0441\u0443\u0434\u0438\u0441\u0442\u043e\u0439 \u0441\u0438\u0441\u0442\u0435\u043c\u0435.<\/p>\n<\/div><\/section><\/div>\n<\/div><\/div><\/div><!-- close content main div --><\/div><\/div><div id='av_section_2'  class='avia-section main_color avia-section-default avia-no-border-styling avia-bg-style-scroll  avia-builder-el-25  el_after_av_four_fifth  avia-builder-el-last   container_wrap sidebar_right' style=' '  ><div class='container' ><div class='template-page content  av-content-small alpha units'><div class='post-entry post-entry-type-page post-entry-678'><div class='entry-content-wrapper clearfix'>\n<div class=\"flex_column av_one_full  flex_column_div av-zero-column-padding first  avia-builder-el-26  avia-builder-el-no-sibling  \" style='border-radius:0px; '><div  class='avia-icon-list-container   avia-builder-el-27  avia-builder-el-no-sibling '><ul class='avia-icon-list avia-icon-list-left av-iconlist-small avia_animate_when_almost_visible avia-iconlist-animate'>\n<li><a href='https:\/\/niox.com.ua\/ru\/faq\/' title='\u0418\u0437\u0443\u0447\u0438\u0442\u0435 \u0447\u0430\u0441\u0442\u043e \u0437\u0430\u0434\u0430\u0432\u0430\u0435\u043c\u044b\u0435 \u0432\u043e\u043f\u0440\u043e\u0441\u044b \u043e NIOX VERO'   style='color:#d33511; font-size:18px; ' class='iconlist_icon  avia-font-entypo-fontello'><span class='iconlist-char ' aria-hidden='true' data-av_icon='\ue87d' data-av_iconfont='entypo-fontello'><\/span><\/a><article class=\"article-icon-entry av-iconlist-empty\"  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='iconlist_content_wrap'><header class=\"entry-content-header\"><div class='av_iconlist_title iconlist_title_small  av_inherit_color '  itemprop=\"headline\"   style='color:#d33511; font-size:18px; 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font-size:18px; '><a href='https:\/\/niox.com.ua\/ru\/instructional-videos\/' title='\u0421\u043c\u043e\u0442\u0440\u0438\u0442\u0435 \u043e\u0431\u0443\u0447\u0430\u044e\u0449\u0438\u0435 \u0432\u0438\u0434\u0435\u043e \u043e NIOX VERO'>\u0421\u043c\u043e\u0442\u0440\u0438\u0442\u0435 \u043e\u0431\u0443\u0447\u0430\u044e\u0449\u0438\u0435 \u0432\u0438\u0434\u0435\u043e \u043e NIOX VERO<\/a><\/div><\/header><div class='iconlist_content av_inherit_color '  itemprop=\"text\"   style='color:#d33511; '><\/div><\/div><footer class=\"entry-footer\"><\/footer><\/article><div class='iconlist-timeline'><\/div><\/li>\n<\/ul><\/div><\/div>\n<\/div><\/div><\/div><!-- close content main div --><\/div><\/div><div id='after_section_2'  class='main_color av_default_container_wrap container_wrap sidebar_right' style=' '  ><div class='container' ><div class='template-page content  av-content-small alpha units'><div class='post-entry post-entry-type-page post-entry-678'><div class='entry-content-wrapper clearfix'>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v20.11 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u041f\u0443\u0431\u043b\u0438\u043a\u0430\u0446\u0438\u0438 \u0438 \u0442\u0435\u0445\u043d\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u0434\u043e\u043a\u0443\u043c\u0435\u043d\u0442\u044b &ndash; 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